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Cheap flight tickets from Medellin to Santo Domingo

Compare Medellin to Santo Domingo flight deals

Find the cheapest month or even day of the year to fly to Santo Domingo

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Flight deals from Medellin to Santo Domingo

Looking for a cheap last-minute deal or the best return flight from Medellin to Santo Domingo? Find the lowest prices on one-way and return tickets right here.
Santo Domingo.RM921 per passenger.Departing Thu, 5 Mar, returning Tue, 10 Mar.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Thu, 5 Mar, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Tue, 10 Mar, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From RM921, select.
Santo Domingo.RM1,000 per passenger.Departing Tue, 17 Mar, returning Tue, 14 Apr.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Tue, 17 Mar, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Tue, 14 Apr, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From RM1,000, select.
Santo Domingo.RM1,000 per passenger.Departing Thu, 23 Apr, returning Tue, 28 Apr.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Thu, 23 Apr, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Tue, 28 Apr, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From RM1,000, select.
Santo Domingo.RM1,033 per passenger.Departing Tue, 2 Jun, returning Sat, 6 Jun.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Tue, 2 Jun, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Sat, 6 Jun, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From RM1,033, select.
Santo Domingo.RM1,072 per passenger.Departing Thu, 9 Jul, returning Thu, 16 Jul.Return flight with Arajet.Outbound indirect flight with Arajet, departs from Medellin Jose Maria Cordova on Thu, 9 Jul, arriving in Santo Domingo Las Americas.Inbound indirect flight with Arajet, departs from Santo Domingo Las Americas on Thu, 16 Jul, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From RM1,072, select.
Santo Domingo.RM1,074 per passenger.Departing Sat, 16 May, returning Mon, 18 May.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Sat, 16 May, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Mon, 18 May, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From RM1,074, select.
Santo Domingo.RM1,092 per passenger.Departing Thu, 26 Feb, returning Tue, 3 Mar.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Thu, 26 Feb, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Tue, 3 Mar, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From RM1,092, select.
Santo Domingo.RM1,093 per passenger.Departing Wed, 1 Jul, returning Mon, 6 Jul.Return flight with Arajet.Outbound direct flight with Arajet departs from Medellin Jose Maria Cordova on Wed, 1 Jul, arriving in Santo Domingo Las Americas.Inbound direct flight with Arajet departs from Santo Domingo Las Americas on Mon, 6 Jul, arriving in Medellin Jose Maria Cordova.Price includes taxes and charges.From RM1,093, select.

Find the cheapest month to fly from Medellin to Santo Domingo

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Medellin to Santo Domingo flights are currently cheapest in March.
Feb
from RM1,197
Mar
from RM921
Apr
from RM1,000
May
from RM1,074
Jun
from RM1,033
Jul
from RM1,072
Aug
from RM1,170
Sep
from RM1,193
Oct
from RM1,167
Nov
from RM1,409
Dec
from RM1,223
Jan
from RM1,193

Direct flights from Medellin to Santo Domingo

Alternative Medellin to Santo Domingo routes

Looking for the cheapest, fastest or easiest route from Medellin to Santo Domingo? You could fly into the following airports instead.

La Isabela International

15km from central Santo Domingo
Closest
Search flights

Santo Domingo Las Americas

23km from central Santo Domingo
Cheapest
from RM921
Search flights

Samana

90km from central Santo Domingo
Search flights

Medellin to Santo Domingo: Flight information

The things to know before you go.
Cheapest flight foundRM921
Cheapest month to flyMarch
Average flight time2 hrs, 32 mins
Most popular airlineArajet
Average flights per week27

Check out these Santo Domingo hotels

Ready to plan your stay? Other travellers rate these Santo Domingo hotels for cleanliness, service and location.
Honky Tonk Colonial
0.57 km from city centre
RM252
Per night
Hotel Aluge
0.33 km from city centre
RM163
Per night
Kimpton LAS Mercedes by IHG
0.16 km from city centre
RM762
Per night
Honky Tonk Colonial
0.57 km from city centre
RM252
Per night
Hotel Aluge
0.33 km from city centre
RM163
Per night
Kimpton LAS Mercedes by IHG
0.16 km from city centre
RM762
Per night
Explore top-rated hotels

Finding cheap flights from Medellin to Santo Domingo: Frequently asked questions

There are 3 airports in Santo Domingo: La Isabela International, Santo Domingo Las Americas and Samana.
The best price we found for a return flight from Medellin to Santo Domingo is RM921. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
2 hours and 32 minutes is the average flight time from Medellin to Santo Domingo.
Arajet, World Ticket Ltd and Copa Airlines Colombia fly direct from Medellin to Santo Domingo.
As of February 2026, there are 27 flights per week flying from Medellin to Santo Domingo.
The cheapest month to fly from Medellin to Santo Domingo is usually March.
If you're flying from Medellin, the cheapest airport near Santo Domingo is Santo Domingo Las Americas – which is 23.4 km away from the centre of Santo Domingo. We've found flights into this airport from RM921.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Medellin to Santo Domingo on Thursday, 5 March 2026.
Yes – the average flight time is 2 hours and 32 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.
In February, the average temperature is usually around 25°C. August is typically the warmest month in Santo Domingo, when it usually averages around 31°C. You can expect the least rain in March. The coldest month is January, with temperatures averaging 21°C. The rainiest month is September.
The cheapest airline that flies to Santo Domingo is Arajet .

Flying from Medellin to Santo Domingo: what you need to know

  • Planning your getaway begins with working out where you'll leave from in Medellin. Jose Maria Cordova International Airport (MDE) is the city's main base, so check out your options for booking a flight from Medellin to Santo Domingo jetting off from here.

  • Las Americas International Airport (SDQ) and Dr. Joaquin Balaguer International Airport (JBQ) are Santo Domingo's chief entry points.

  • The average length of a direct Medellin to Santo Domingo flight is 2 hours 35 minutes.

  • The timezone in Santo Domingo is UTC-4, which is one hour ahead of Medellin.

  • The busiest route for flights from Medellin to Santo Domingo is from Jose Maria Cordova International Airport (MDE) to Las Americas International Airport (SDQ). Choose from nine services every week between these two airports. If you want to take off at the first opportunity, the earliest flight from MDE to SDQ is the 05:47 Wingo option. If you prefer to leave later in the day, the last available departure is at 21:27 with Arajet.

  • Give yourself plenty of time to get on your Medellin to Santo Domingo flight. It's generally best to arrive at least two hours before international departures and an hour ahead for domestic flights.

  • Flying during a popular month like August? Major public holidays and other high seasons can lead to longer queues at check-in and security. Play it safe and arrive up to four hours before an international flight and two hours before domestic departures.

How to find the cheapest flights from Medellin to Santo Domingo

  • The cheapest price we've seen for a one-way ticket from Medellin to Santo Domingo is RM579. For a return flight on this route, the best price is RM921. Depending on the availability and when you book, these fares can change.

  • Book six months before you want to travel. Pricing trends suggest that this is the ideal window for finding cheap Medellin to Santo Domingo flights.

  • September is the best month for nabbing a fantastic deal on a plane ticket from Medellin to Santo Domingo. If you'd like to travel at a different time of year, the 'Whole month' tool will show you the lowest prices across every month.

  • There's no need to search every day to see if fares have dropped when you set up a Price Alert. We'll tell you the moment there's a better deal on cheap flights from Medellin to Santo Domingo.

  • Choose your preferred departure and arrival times, airlines and number of stops with the filters. Alternatively, sort your Medellin to Santo Domingo flight results by 'Best,' 'Fastest' or 'Cheapest.'

Flying from Medellin

Jose Maria Cordova International Airport (MDE)

  • If you're looking for a direct flight from Medellin to Santo Domingo, you can depart from Jose Maria Cordova International Airport (MDE). Fly from MDE to Las Americas International Airport (SDQ) without making any stops.

  • Arajet is a popular airline that offers direct Medellin to Santo Domingo plane tickets leaving from MDE.

  • We make it a cinch to book a Medellin to Santo Domingo flight with a stopover. To see the options leaving from Jose Maria Cordova International Airport, uncheck 'Direct flights only.' Next, choose a flight with a stop long enough to see the sights of your chosen city. Top stopovers include:

    • El Dorado International Airport (BOG)

    • Rafael Nunez International Airport (CTG)

    • Simon Bolivar International Airport (CCS)

  • MDE is about 18 kilometres from central Medellin. If you're catching a cab, ride-sharing or driving from the centre, it'll take 35 minutes or so to arrive, depending on the traffic.

  • Looking for a convenient hotel near Jose Maria Cordova International Airport? If you've booked an early flight from Medellin to Santo Domingo, these stays will have you sleeping moments from your check-in counter:

  • 69.76% of flights that depart Jose Maria Cordova International Airport land at their destination on schedule.

Arriving in Santo Domingo

Las Americas International Airport (SDQ)

Dr. Joaquin Balaguer International Airport (JBQ)

  • Dr. Joaquin Balaguer International Airport (JBQ) is about 13 kilometres from central Santo Domingo. Following your flight from Medellin to Santo Domingo, it takes approximately 25 minutes to get to the heart of the city in a cab or ride-share.

  • Unpack your bags not long after your flight from Medellin to Santo Domingo at Moderno Apartamento Para tu Estancia. This comfy accommodation option is a short drive from JBQ.

  • Pick up a Dr. Joaquin Balaguer International Airport rental car and expand your travel horizons with your own set of wheels. FlexWays is just moments from baggage claim, ensuring a fast and easy pick-up.

  • Avoid the long lines and paperwork at the rental desk by completing your booking beforehand. Reserve your ride from JBQ ahead of time so you can simply grab the keys and get going.

Best time to go to Santo Domingo

  • It's time to choose your travel dates for your flight from Medellin to Santo Domingo. January is the most popular month to visit Santo Domingo. If you like a more peaceful vibe, go in May.

  • Book a Medellin to Santo Domingo ticket departing in September if you're eager to visit the city during its warmest month. Expect temperatures in Santo Domingo to range from 23ºC (73ºF) to 33ºC (91ºF).

  • Search for cheap flights from Medellin to Santo Domingo in February if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 19ºC (66ºF) and 29ºC (84ºF) on average.

More about Santo Domingo

  • Start your Santo Domingo trip off on the right foot by choosing the perfect place to stay. After booking your flight from Medellin to Santo Domingo, check out our range of hotels including:

  • Every great holiday has to include some sightseeing. Alcazar de Colon, National Palace and Basilica Cathedral of Santa Maria la Menor are must-do's during your Santo Domingo adventure.

Explore more of Dominican Republic

  • You've visited Santo Domingo, now it's time to explore more of Dominican Republic. Journey around 13 kilometres east to Santo Domingo Este to check off its must-visit sights. From Museo Las Tres Aves to billeteros Park and Abuela Mota Final Resting Place, your itinerary will be busy.

  • Around 64 kilometres east of Santo Domingo, San Pedro de Macorís is another essential stop in Dominican Republic. No visit is complete without checking out El Parquecito, Patrimonio arquitectónico de la ciudad de San Pedro de Macoris and Museo Cultural San Pedro.

Plan the rest of your trip from Medellin to Santo Domingo

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.